| Abkürzung | Bereich | Staat | Bedeutung |
| S | Physik | D | Querschnittsfläche |
| s | Physik | D | Weglänge |
| S-VHS | Technik | Super VHS | |
| SAP | Firma | D | Systeme, Anwendungen, Produkte |
| SB | Allgemein | D | Selbstbedienung |
| Computer | Soundblaster | ||
| SBCS | Software | Single Byte Character Set | |
| SCC | Computer | Serial Controller Chip | |
| SCCS | Software | Source Code Control System | |
| SCD | Computer | Standard Color Display | |
| SCRN | Computer | Screen | |
| SCSI | Computer | Small Computer Systems Interface | |
| SD | Computer | Send Data | |
| Single Density | |||
| Structured Design | |||
| SDA | Computer | Software Disk Array | |
| Source Data Automation | |||
| System Display Architecture | |||
| SDI | Software | Single Document Interface | |
| SDK | Software | Software Developer's Kit | |
| SDMS | Computer | SCSI Device Management System | |
| SEG | Computer | Segment | |
| Seg. | Allgemein | D | Segment |
| SEL | Computer | Selection | |
| SER | Computer | Serial | |
| SEU | Computer | Smallest Executable Unit | |
| SF | Allgemein | Science Fiction | |
| Computer | Sign Flag | ||
| SFT | Computer | System File Table | |
| SGEN | Computer | Signal Generator | |
| SGI | Firma | USA | Silicon Graphics Inc. |
| SGML | Computer | Standard Generalized Markup Language | |
| SID | Computer | Station Identification | |
| SIM | Computer | Simulator | |
| SIMM | Computer | Single Inline Memory Module | |
| sin | Mathematik | Sinus | |
| SIO | Computer | Serial Input / Output | |
| SIPO | Computer | Serial In - Parallel Out | |
| SISO | Computer | Serial In - Serial Out | |
| SLIP | Computer | Serial Line Interface Protocol | |
| SM | Allgemein | Sado Maso (Sadomasochismus) | |
| Computer | Set Mode | ||
| SMB | Computer | Server Message Block | |
| SMBP | Computer | Server Message Block Protocol | |
| SMI | Computer | System Management Interrupts | |
| SMK | Computer | Software Migration Kit | |
| SMP | Computer | Symmetrical Multiprocessor | |
| SMPS | Computer | Switching Mode Power Supply | |
| SMRAM | Computer | System Management Random Access Memory | |
| SMPT | Computer | Simple Mail Transfer Protocol | |
| SN | Allgemein | Serial Number (Seriennummer) | |
| SNA | Computer | Systems Network Architecture | |
| SNAP | Computer | Subnet Access Protocol | |
| SND | Computer | Sound | |
| SNMP | Computer | Simple Network Management Protocol | |
| SOM | Computer | System Object Model | |
| SOP | Computer | Standard Operating Procedures | |
| SOX | Computer | Sound Exchange | |
| SP | Computer | Service Pack | |
| Stack Pointer | |||
| SPARC | Computer | Scalable Processor Architecture | |
| SPC | Computer | Small Peripheral Controller | |
| SPD | Partei | D | Sozialdemokratische Partei Deutschlands |
| spez. | Allgemein | D | spezifische |
| SPI | Computer | Service Provider Interface | |
| SPM | Computer | System Performance Monitor | |
| SPOOL | Computer | Simultaneous Peripheral Operations On Line | |
| SPS | Technik | Speicherprogrammierte Steuerung | |
| SPT | Computer | Sectors p/er Track | |
| SQL | Computer | Structured Query Language | |
| SRAM | Computer | Static Random Access Memory | |
| SS | Computer | Single Sided | |
| Stack Segment | |||
| SSD | Computer | Solid State Disk | |
| SSDC | Computer | Stack Segment Descriptor Cache | |
| Std. | Allgemein | D | Standard |
| STDAUX | Computer | Standard Auxillary | |
| STDIN | Computer | Standard In | |
| STDOUT | Computer | Standard Out | |
| STDPRN | Computer | Standard Printer | |
| STI | Computer | Set Interrupt Flag | |
| STOS | Computer | Store String | |
| STP | Technik | Shielded Twisted Pair | |
| Stud. | Allgemein | D | Student |
| STX | Computer | Start of Text | |
| SUB | Computer | Subroutine | |
| SunOS | Software | Sun Operating System | |
| SVGA | Computer | Super Video Graphics Array | |
| SW | Computer | Shareware | |
| SYNC | Allgemein | Synchronous (Synchron) | |
| SYSLOG | Computer | System Log | |
| SYSMOD | Computer | System Modification | |
| SYSOP | Computer | System Operator | |
| SYSREQ | Computer | System Request |